Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc ...

In vitro fertilization is clearly a successful technology, although it remains experimental; the safety and efficacy of new methods and reagents can be difficult to assess. And “traditional ...

Endovascular thrombectomy has been shown to be safe and effective in selected patients with acute ischemic stroke due to large-vessel occlusion (LVO) up to 24 hours after symptom onset.1 In pivotal ...

The author describes pronuclear transfer, a type of mitochondrial donation, which was made available to women with mitochondrial DNA disease in a reproductive care pathway implemented in Newcastle, ...

Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying pathog ...

In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone ...

NEJM uses highly rigorous editorial, peer, and statistical review processes to evaluate manuscripts for scientific accuracy, novelty, and importance.

In the current anti-immigrant political environment in the United States, what will happen when immigrants who work in the health care system are forced to leave?

Ondansetron improves outcomes when administered in emergency departments to children with acute gastroenteritis–associated vomiting. It is commonly prescribed at discharge to reduce symptoms ...

AI mammography aids are being sold as additions to mammography screening, with direct-to-consumer marketing touting improved cancer-detection rates, despite a lack of evidence of clinical effective ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 2).

The U.S. Supreme Court recently upheld Tennessee’s ban on gender-affirming hormonal treatment for transgender minors. This decision will have profound implications.