本研究针对老年患者使用阿哌沙班 (apixaban)时肾功能对药物代谢的影响这一临床难题，通过前瞻性观察36名≥65岁急性住院患者，首次揭示严重肾功能不全 (GFR<30 ml/min)患者需减少70%剂量才能避免出血风险。研究采用UPLC-MS/MS精准检测血清浓度，为DOACs个体化用药提供了关键循证依据。

Apixaban would still cost patients 9 times more through the Eliquis 360 Support program than with commercial insurance.

Pfizer (PFE), in collaboration with Bristol Myers Squibb, has introduced a direct-to-patient option for Eliquis®, potentially ...

Apixaban tied to less stroke and bleeding in patients with/without dementia vs. dabigatran, rivaroxaban or warfarin. Image: Adobe Stock “The prescribing decisions for oral anticoagulants need to ...

Apixaban has also been evaluated for stroke prevention in AF in two Phase III trials, one of which was recently completed. Both include patients with one or more additional stroke risk factors ( ...

Apixaban 5 mg orally twice daily (2.5 mg twice daily in selected patients) Aspirin 81–324 mg orally once daily. Duration determined by events. ARISTOTLE 60,61: 18,206: ...

Apixaban was also more clinically effective than dabigatran etexilate and enoxaparin. Both apixaban and rivaroxaban dominated dabigatran etexilate and enoxaparin in the analyses for total knee ...

Apixaban was not superior to standard of care antithrombotic treatment for preventing thrombotic or bleeding events after successful transcatheter aortic valve replacement, regardless of ...

In the overall trial, apixaban was not superior to standard care for the prevention of clinical events, irrespective of the need for oral anticoagulation. In the substudy, investigators evaluated the ...