This series of systematic reviews was commissioned by WHO in July 2022 to inform their guideline review process. The aim was to identify the current evidence for developing WHO guidelines for the ...

Objectives Sleep-disordered breathing is a key childhood complication in children with achondroplasia. This retrospective study aimed to document the prevalence of sleep-disordered breathing in ...

Emperor Joseph II: My dear young man, don't take it too hard. Your work is ingenious. It's quality work. And there are simply too many notes, that's all. Just cut a few and it will be perfect.Mozart: ...

The most recent in a series of dangerous social media trends has seen children ingesting large quantities of nutmeg in an attempt to gain a natural ‘high’. Over the past 20 years, there has been a ...

Objectives To estimate the incidence of clinically diagnosed congenital adrenal hyperplasia (CAH), clinical features and age at first presentation. To assess the potential benefit of newborn screening ...

Objective Routine varicella zoster vaccination for children aged 18 months began in Australia from November 2005. The aim of this study was to compare the current incidence and outcomes of congenital ...

BACKGROUND Antenatal screening for cystic fibrosis has been endorsed by the US National Institutes of Health. Edinburgh is the only city in the UK with an established routine antenatal screening ...

Premature adrenarche (PA) is characterised by early maturation of the zona reticularis of the adrenal gland before 8 and 9 years in girls and boys, respectively.1 Biochemical analysis of androgens is ...

> Optimism is a good characteristic, but if carried to an excess, it becomes foolishness. Theodore Roosevelt1 We would define an innovative therapy as any newly introduced treatment, or a new ...

Background Cognitive ability and socioemotional behaviour during childhood have independently been shown to impact educational outcomes. The extent to which their co-development predicts these ...

Objective The aim of this research was to ascertain the effectiveness of current electronic prescribing (EP) systems to prevent a standardised set of paediatric prescribing errors likely to cause harm ...

Objective Neural tube defects (NTDs) are a preventable folate deficiency disorder; increasing folic acid intake through food fortification increases serum and red blood cell folate and reduces the ...