Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc ...

In vitro fertilization is clearly a successful technology, although it remains experimental; the safety and efficacy of new methods and reagents can be difficult to assess. And “traditional ...

The author describes pronuclear transfer, a type of mitochondrial donation, which was made available to women with mitochondrial DNA disease in a reproductive care pathway implemented in Newcastle, ...

Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying pathog ...

Ondansetron improves outcomes when administered in emergency departments to children with acute gastroenteritis–associated vomiting. It is commonly prescribed at discharge to reduce symptoms ...

In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 2).

Endovascular thrombectomy has been shown to be safe and effective in selected patients with acute ischemic stroke due to large-vessel occlusion (LVO) up to 24 hours after symptom onset.1 In pivotal ...

This review discusses the features of oligoarticular, polyarticular, systemic, and psoriatic JIA and enthesitis-related arthritis, as well as advances in treatment for these conditions.

Cardiovascular diseases, principally ischemic heart disease and stroke, have consistently been the leading cause of death worldwide since 1990 and accounted for 19.8 million deaths in 2022 alone.1 ...

In the current anti-immigrant political environment in the United States, what will happen when immigrants who work in the health care system are forced to leave?

The financial assistance policies of some U.S. hospitals now define medical necessity much more restrictively than it has conventionally been understood, as covering only services that are ...